Psoriasis treatments come in 3 forms: topical, light therapy and systematic medication. Topical and light therapy psoriasis treatments have both already been discussed in Topical Psoriasis Treatments and Light Therapy Psoriasis Treatments, so this article will solely be devoted to the discussion of psoriasis treatments via systematic medication.
By definition, systematic medications are medications that affect the entirety of the body’s systems. Unlike topical and light therapy treatments, systematic medications are typically only used as psoriasis treatments on individuals who suffer from moderate to severe cases of psoriasis. In fact, many dermatologists won’t even consider putting their psoriasis-laden patients on systematic medications until all other treatment types have been exhausted and found ineffective. Having said that, systematic medications normally come with the chance of severe side effects. As a result, dermatologists who end up prescribing them to their patients will often closely monitor them in a pre-emptive effort to avoid those severe side effects.
That being said, the following are the systematic treatments for psoriasis that are most commonly prescribed by dermatologists: methotrexate, cyclosporine and retinoids.
To begin, methotrexate is a medication that can be taken either by mouth or via an injection. On the fundamental level, methotrexate functions by suppressing the immune system. Ultimately, this suppression of the immune system leads to the reduction of the effects of psoriasis. It does this by binding with, and then stopping, the cells that are commonly associated with the growth of skin. Taken in the short term, methotrexate has been found to be an effective psoriasis treatment. However, over the long term it can cause irreperable liver and blood cell damage.
Having said that, cyclosporine functions in almost the exact same way as methotrexate. So, next up is retinoids.
Retinoids, a derivative of vitamin A, functions by altering the method of growth and process of shedding undergone by skin cells. When taken by itself, retinoids do wonders for individuals who have pustular psoriasis or erythrodermic psoriasis. But, they are also beneficial for those individuals with plaque psoriasis as long as they are combined with phototherapy. All things considered, retinoids can cause severe birth defects even after the individual has stopped taking them, so dermatologists typically recommend that women should not be pregnant when they begin taking retinoids, or have plans on becoming pregnant within three years after they’ve stopped taking them.

